Description

1,2-Pyrrolidinedicarboxylic Acid, 4-[[(2-Propen-1-Yloxy)Carbonyl]Amino]-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2R,4R)- is a high-purity, stereochemically defined building block designed for advanced organic synthesis. This compound is of significant value for its role as a protected amino acid derivative, facilitating the controlled construction of complex peptide and peptidomimetic structures. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected, side-chain functionalized proline analog for the assembly of specialized peptide sequences.
• Peptidomimetic Drug Discovery: Used as a constrained scaffold to introduce specific conformational and functional properties into drug candidates targeting enzymes and receptors.
• Pharmaceutical Intermediate: Acts as a critical chiral intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs) with defined stereochemistry.
• Bioconjugation Chemistry: The allyloxycarbonyl (Alloc) protecting group allows for orthogonal deprotection strategies, enabling selective modification in complex molecular systems.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged peptides for studying protein-protein interactions and cellular pathways.
• Academic & Industrial R&D: A valuable reagent for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1,2-Pyrrolidinedicarboxylic Acid, 4-[[(2-Propen-1-Yloxy)Carbonyl]Amino]-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2R,4R)-
CAS No.	2415967-27-8
Molecular Formula	C24H24N2O6
Molecular Weight	436.46 g/mol
Synonyms	(2R,4R)-Fmoc-4-[(Alloc)amino]proline; (2R,4R)-1-Fmoc-4-[(Alloc)amino]pyrrolidine-2-carboxylic acid; Fmoc-(2R,4R)-4-[(Alloc)amino]Pro-OH; Fmoc-4-[(Alloc)amino]-D-proline; 4-[(Allyloxycarbonyl)amino]-1-(9H-fluoren-9-ylmethyl) (2R,4R)-pyrrolidine-1,2-dicarboxylate; (2R,4R)-4-[[(Allyloxy)carbonyl]amino]-1-(9H-fluoren-9-ylmethyl) pyrrolidine-1,2-dicarboxylate; (2R,4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-propen-1-yloxycarbonyl)amino]pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥95% (by HPLC), meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Our quality management system supports the needs of customers operating under cGMP and ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.