Description

n-Fmoc-4-Methyl-D-Tryptophan CAS NO 2415937-11-8 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis and pharmaceutical research. This compound is critical for introducing the unique structural and functional properties of the 4-methyl-D-tryptophan residue into peptide chains, enabling the development of novel bioactive molecules. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors focused on peptide-based drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, facilitating the controlled assembly of complex peptides.
• Pharmaceutical Intermediates: Serves as a crucial precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptidomimetic Design: Used to create analogs and mimetics with enhanced metabolic stability, receptor selectivity, or bioavailability.
• Bioconjugation and Labeling: The tryptophan moiety and Fmoc-protecting group provide handles for further chemical modification and labeling studies.
• Academic and Industrial R&D: Fundamental research tool for studying protein-protein interactions, enzyme substrates, and structure-activity relationships (SAR).
• Production of Specialty Peptides: Manufacture of custom peptides for diagnostic, therapeutic, and research applications requiring the D-isomer configuration.

Basic Information

Product Name	n-Fmoc-4-Methyl-D-Tryptophan
CAS No.	2415937-11-8
Molecular Formula	C28H26N2O4
Molecular Weight	454.52 g/mol
Synonyms	Fmoc-4-Me-D-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methyl-D-tryptophan; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-methyl-1H-indol-3-yl)propanoic acid; 4-Methyl-D-tryptophan, N-Fmoc derivative; Fmoc-D-4-methyltryptophan; N-α-Fmoc-4-methyl-D-tryptophan; Fmoc-4-methyl-D-Trp; 4-Me-D-Trp(Fmoc)-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-4-Methyl-D-Tryptophan is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP manufacturing. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for peptide synthesis building blocks, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere (e.g., nitrogen or argon) when not in use to maintain stability and prevent degradation. For long-term storage, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.