Description

Fmoc-Lys-Otbu.Hcl is a protected amino acid derivative widely used in solid-phase peptide synthesis (SPPS). This compound is essential for the controlled elongation of peptide chains, offering orthogonal protection for the lysine side chain. It is a critical building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and biochemical tools. Its high purity and reliable performance are fundamental for ensuring the success and reproducibility of complex peptide assembly.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated or manual synthesis of peptides and proteins.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting various diseases.
• Bioconjugation and Labeling: Serves as a precursor for introducing functional handles or labels at specific lysine residues within a peptide sequence.
• Combinatorial Chemistry: A key component in libraries for drug discovery and screening of bioactive peptide candidates.
• Biochemical Research: Employed in studying protein-protein interactions, enzyme substrates, and receptor ligands.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Can be utilized in the design and synthesis of specialized linkers for targeted drug delivery systems.

Basic Information

Product Name	Fmoc-Lys-Otbu.Hcl
CAS No.	2413365-23-6
Molecular Formula	C26H34N2O5 • HCl
Molecular Weight	491.02 g/mol (Free base: 454.56)
Synonyms	Fmoc-Lys(OtBu)-OH•HCl; Nα-Fmoc-Nε-tert-butyloxycarbonyl-L-lysine hydrochloride; Fmoc-Lys(Boc)-OH•HCl (common misnomer for OtBu); (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxy)carbonyl)amino)hexanoic acid hydrochloride; Fmoc-Lys(tBu)-OH•HCl; Nα-Fmoc-Nε-Boc-L-lysine hydrochloride (common alias); Fmoc-L-lysine(OtBu) hydrochloride; Fmoc-Lys(OtBu)-OH hydrochloride salt
EINECS	Contact for details

Quality Control

Our Fmoc-Lys-Otbu.Hcl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for each lot to guarantee traceability and batch-to-batch consistency for your critical research and cGMP manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.