Description

Fmoc-2-Amino-5,5,5-F-n-Me-L-Norvaline CAS NO 2407820-18-0 is a specialized, non-natural amino acid derivative featuring a fluorinated side chain and an N-terminal Fmoc protecting group. This compound is critical for the solid-phase peptide synthesis (SPPS) of peptides designed with enhanced metabolic stability, altered lipophilicity, and specific bioactivity profiles. It is an essential building block for pharmaceutical researchers and peptide manufacturers developing novel therapeutics, diagnostic agents, and biochemical tools. The unique trifluoromethyl group introduces desirable physicochemical properties into peptide sequences, making it valuable for advanced drug discovery programs.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as a fluorinated, sterically hindered amino acid building block for automated peptide synthesizers.
• Pharmaceutical R&D: Incorporation into peptide-based drug candidates to improve metabolic stability, membrane permeability, and binding affinity.
• Peptidomimetic Design: Key intermediate for creating analogs that mimic natural peptides but with enhanced pharmacological properties.
• Bioconjugation & Probe Development: Used in the synthesis of fluorinated peptides for imaging studies, such as PET tracer development, due to the presence of fluorine atoms.
• Academic & Institutional Research: Employed in biochemical studies to investigate the role of specific amino acid substitutions on protein structure and function.
• Custom Peptide Service Providers: A critical raw material for CROs and CDMOs offering bespoke peptide synthesis services to the biotech industry.

Basic Information

Product Name	Fmoc-2-Amino-5,5,5-F-n-Me-L-Norvaline
CAS No.	2407820-18-0
Molecular Formula	C₂₂H₂₂F₃NO₄
Molecular Weight	421.41 g/mol
Synonyms	Fmoc-2-Amino-5,5,5-trifluoro-n-methyl-L-norvaline; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-amino-5,5,5-trifluoro-n-methyl-L-norvaline; Fmoc-2-Am-5,5,5-F3-n-Me-L-Nva; Fmoc-(2-N-Me)-TfnV-OH; Fmoc-N-methyl-2-amino-5,5,5-trifluoronorvaline; (2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino}-5,5,5-trifluoropentanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-2-Amino-5,5,5-F-n-Me-L-Norvaline is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for demanding pharmaceutical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, assay, and impurity profiles. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.