Description

Thalidomide-o-Peg4-Amine is a high-purity, functionalized PEG linker derivative designed for advanced bioconjugation and pharmaceutical research. This compound is engineered to serve as a critical building block for the development of antibody-drug conjugates (ADCs), targeted therapeutics, and PROTACs, enabling precise drug delivery and enhanced pharmacokinetic properties. It is essential for researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors who require reliable, well-characterized intermediates for complex molecular assembly.

Application

• Antibody-Drug Conjugate (ADC) Development: Serves as a cleavable or non-cleavable linker to connect cytotoxic payloads to monoclonal antibodies.
• PROTAC (Proteolysis Targeting Chimera) Synthesis: Used as a spacer to connect an E3 ligase ligand to a target protein ligand, facilitating targeted protein degradation.
• Bioconjugation and Labeling: The amine terminus allows for conjugation to carboxylic acids, activated esters, or other reactive groups on proteins, peptides, or small molecules.
• Polyethylene Glycol (PEG) Modification: Acts as a functionalized PEG derivative to improve solubility, reduce immunogenicity, and prolong circulation half-life of therapeutic agents.
• Prodrug Synthesis: Utilized to create prodrugs where the active pharmaceutical ingredient (API) is released upon specific biological triggers.
• Chemical Biology Probes: Enables the creation of molecular probes for studying protein function, localization, and interaction networks.

Basic Information

Product Name	Thalidomide-o-Peg4-Amine
CAS No.	2401832-00-4
Molecular Formula	C31H40N4O11
Molecular Weight	644.67 g/mol
Synonyms	Thalidomide-PEG4-NH2; Thalidomide-O-(PEG)4-Amine; (S)-2-(2-(2-(2-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)amino)acetic acid; 4-((2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Thalidomide-PEG4-C2-Amine; E3 Ligase Ligand-PEG4-NH2; Cereblon Ligand-PEG4-Amine; PROTAC Linker 4
EINECS	Contact for details

Quality Control

Our Thalidomide-o-Peg4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every lot. We adhere to cGMP guidelines for the production of pharmaceutical intermediates to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially light-sensitive nature. For long-term storage, desiccate. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.