Description

8-Benzyloxy-3'-Deoxy-3'-Fluoroguanosine is a modified nucleoside analog, a key synthetic intermediate in medicinal chemistry research. This compound matters for its role in the development of novel antiviral and anticancer therapeutics, particularly as a precursor for modified oligonucleotides and prodrugs. Pharmaceutical R&D laboratories and fine chemical manufacturers specializing in nucleoside chemistry are the primary users of this high-value building block.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the development of prodrugs targeting viral polymerases, with potential applications against a range of viruses.
• Oligonucleotide Synthesis: Serves as a modified monomer for creating fluorinated and benzyl-protected oligonucleotides for antisense and siRNA applications.
• Biochemical Probe Development: Utilized in creating labeled or modified nucleotides to study enzyme mechanisms and nucleic acid interactions.
• Medicinal Chemistry SAR Studies: Enables structure-activity relationship studies by introducing specific modifications at the 3'-position of the sugar moiety.
• Preclinical Candidate Synthesis: Employed in the gram-to-kilogram scale synthesis of drug candidates for preclinical evaluation.

Basic Information

Product Name	8-Benzyloxy-3'-Deoxy-3'-Fluoroguanosine
CAS No.	2389988-61-6
Molecular Formula	C₁₇H₁₈FN₅O₄
Molecular Weight	375.36 g/mol
Synonyms	3'-Deoxy-3'-fluoro-8-benzyloxyguanosine; 8-O-Benzyl-3'-deoxy-3'-fluoroguanosine; 3'-Fluoro-3'-deoxy-8-benzyloxyguanosine; Guanosine, 8-(benzyloxy)-3'-deoxy-3'-fluoro-; 8-Benzyloxy-3'-fluoro-3'-deoxyguanosine; 2389988-61-6; 8-BnO-3'-F-3'-dG
EINECS	Contact for details

Quality Control

Our 8-Benzyloxy-3'-Deoxy-3'-Fluoroguanosine is manufactured under strict quality management systems to ensure batch-to-batch consistency for research and development. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis, NMR and MS confirmation of structure, and determination of residual solvents and moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. Due to its hygroscopic nature, the container should be kept in a desiccated environment and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.