Description

2-Chloro-3-Fluoro-4-(Trifluoromethyl)Benzaldehyde is a high-purity fluorinated aromatic aldehyde building block of significant interest in advanced organic synthesis. Its value lies in its unique substitution pattern, which introduces multiple halogen and trifluoromethyl groups onto a benzaldehyde core, enabling precise modulation of electronic and steric properties in target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for applications requiring enhanced metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated ligands and core structures in electronic materials, where its properties can influence charge transport and emission characteristics.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, nucleophilic aromatic substitution, and as a precursor to corresponding acids, alcohols, and amines for library synthesis.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating complex molecular architectures.

Basic Information

Product Name	2-Chloro-3-Fluoro-4-(Trifluoromethyl)Benzaldehyde
CAS No.	2385871-45-2
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	4-(Trifluoromethyl)-2-chloro-3-fluorobenzaldehyde; 2-Chloro-3-fluoro-4-trifluoromethylbenzaldehyde; 2-Chloro-3-fluoro-alpha,alpha,α-trifluoro-p-tolualdehyde; Benzaldehyde, 2-chloro-3-fluoro-4-(trifluoromethyl)-; 2385871-45-2 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Fluoro-4-(Trifluoromethyl)Benzaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and scale-up. Our products undergo rigorous quality testing, including HPLC, GC, NMR, and MS analysis, to ensure compliance with customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.