Description

Fmoc-Trp(7-Cl)-Oh is a protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled introduction of the 7-chlorotryptophan residue, enabling the synthesis of complex peptides with enhanced biological activity and stability. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential assembly of custom peptides, particularly those requiring site-specific incorporation of halogenated tryptophan.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Chemical Biology & Proteomics: Enables the synthesis of peptide probes, activity-based protein profiling (ABPP) reagents, and isotopically labeled peptides for mass spectrometry.
• Antimicrobial Peptide (AMP) Development: Facilitates the creation of novel AMPs where halogenation can modulate hydrophobicity, membrane interaction, and potency.
• Peptide Library Construction: An essential component for generating diverse combinatorial peptide libraries for high-throughput screening against biological targets.
• Bioconjugation & Material Science: Serves as a precursor for creating peptide-functionalized surfaces, biomaterials, and drug delivery conjugates.

Basic Information

Product Name	Fmoc-Trp(7-Cl)-Oh
CAS No.	2382374-53-8
Molecular Formula	C26H21ClN2O4
Molecular Weight	460.91 g/mol
Synonyms	Fmoc-7-chloro-L-tryptophan; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-7-chloro-L-tryptophan; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(7-chloro-1H-indol-3-yl)propanoic acid; Fmoc-7-Cl-Trp-OH; Fmoc-L-Trp(7-Cl)-OH; Nα-Fmoc-7-chlorotryptophan; Fmoc-7-chlorotryptophane; Fmoc-Trp(7-Cl)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Trp(7-Cl)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation, to ensure it meets the stringent requirements of advanced peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.