Description

Pyrido[3,2-D]Pyrimidine, 7-Bromo-4-Chloro-2-(Difluoromethyl)- is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its complex molecular architecture, featuring halogen and difluoromethyl substituents, makes it a critical intermediate for constructing novel pharmacologically active compounds. This product is primarily targeted at pharmaceutical R&D and fine chemical manufacturers engaged in developing next-generation therapeutics, particularly kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key scaffold in the synthesis of targeted cancer therapies, kinase inhibitors, and other bioactive molecules.
• Agrochemical Research: Used in developing novel active ingredients for crop protection with enhanced efficacy.
• Material Science: Serves as a precursor for organic electronic materials and specialty polymers.
• Chemical Biology: Employed as a probe or ligand in the study of enzyme mechanisms and protein interactions.
• Academic & Contract Research: Essential for medicinal chemistry programs in universities and CROs (Contract Research Organizations).
• Custom Synthesis: A versatile starting point for the preparation of complex, fluorinated heterocyclic libraries.

Basic Information

Product Name	Pyrido[3,2-D]Pyrimidine, 7-Bromo-4-Chloro-2-(Difluoromethyl)-
CAS No.	2377656-18-1
Molecular Formula	C9H4BrClF2N3
Molecular Weight	307.50 g/mol
Synonyms	7-Bromo-4-chloro-2-(difluoromethyl)pyrido[3,2-d]pyrimidine; 2-(Difluoromethyl)-7-bromo-4-chloropyrido[3,2-d]pyrimidine; 4-Chloro-7-bromo-2-(difluoromethyl)pyrido[3,2-d]pyrimidine; Pyrido[3,2-d]pyrimidine, 7-bromo-4-chloro-2-(difluoromethyl)-; 2377656-18-1; 7-Bromo-4-chloro-2-difluoromethyl-pyrido[3,2-d]pyrimidine
EINECS	Contact for details

Quality Control

Our Pyrido[3,2-D]Pyrimidine derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with ICH guidelines and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time matches reference standard
Identification (IR)	Spectrum conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.