Description

2-Methoxy-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine is a high-purity, advanced pharmaceutical intermediate featuring a pyrimidine core functionalized with a pinacol boronate ester group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient Suzuki-Miyaura cross-coupling reactions for the synthesis of complex bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel drug candidates and active ingredients. The CAS number for this compound is 2369772-10-9.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs) for oncology, antiviral, and central nervous system (CNS) drugs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boron-containing coupling partner for constructing biaryl and heterobiaryl systems prevalent in modern drug discovery.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides by introducing the pyrimidine-boronate moiety into lead structures.
• Material Science Precursor: Potential building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for target identification and binding studies.
• Process Chemistry & Scale-up: Suitable for development from milligram to kilogram scale under GMP-like conditions for clinical trial material production.

Basic Information

Product Name	2-Methoxy-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine
CAS No.	2369772-10-9
Molecular Formula	C12H19BN2O3
Molecular Weight	250.11 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methoxy-4-methylpyrimidine; 2-Methoxy-4-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 5-Pyrimidineboronic acid, 2-methoxy-4-methyl-, pinacol ester; 2369772-10-9; 2-Methoxy-4-methylpyrimidine-5-boronic acid pinacol ester; 4-Methyl-2-methoxypyrimidine-5-boronic acid pinacol ester.
EINECS	Contact for details

Quality Control

Our 2-Methoxy-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports research and development as well as cGMP-compliant production requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage at 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.