Description

2-Bromo-3-Chloro-6-Fluoro-4-Methyl-Benzaldehyde is a highly functionalized benzaldehyde derivative, serving as a critical multi-halogenated aromatic building block in advanced organic synthesis. Its precise substitution pattern makes it an indispensable precursor for constructing complex molecular architectures where specific halogen atoms are required for subsequent coupling or substitution reactions. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Employed in the synthesis of specialized ligands, organic semiconductors, and liquid crystals due to its electron-withdrawing halogen substituents.
• Cross-Coupling Reactions: Serves as a versatile substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, where the bromo and chloro groups act as orthogonal reactive sites.
• Chemical Biology Probes: Utilized in the design and synthesis of chemical probes and tags for studying biological systems and protein interactions.

Basic Information

Product Name	2-Bromo-3-Chloro-6-Fluoro-4-Methyl-Benzaldehyde
CAS No.	2368909-40-2
Molecular Formula	C8H5BrClFO
Molecular Weight	251.48 g/mol
Synonyms	4-Methyl-2-bromo-3-chloro-6-fluorobenzaldehyde; 2-Bromo-3-chloro-6-fluoro-p-tolualdehyde; 6-Fluoro-2-bromo-3-chloro-4-methylbenzaldehyde; Benzaldehyde, 2-bromo-3-chloro-6-fluoro-4-methyl-; 2368909-40-2; BCFM-Benzaldehyde
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Chloro-6-Fluoro-4-Methyl-Benzaldehyde is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, handling should be performed under appropriate conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.