Description

2-(Pyrrolidin-1-Yl)Pyrimidine-4-Carboxylic Acid Hydrochloride is a high-purity pharmaceutical intermediate and building block of significant importance in modern drug discovery. Its core value lies in its functionalized pyrimidine-pyrrolidine scaffold, which is highly sought after for the synthesis of bioactive molecules targeting various therapeutic areas. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality building blocks for lead optimization and process development.

Application

This versatile chemical intermediate serves as a critical precursor in several advanced synthetic pathways. Key application areas include:

• Pharmaceutical Intermediate: Core building block for the synthesis of novel small-molecule drugs, particularly kinase inhibitors and other enzyme-targeting therapeutics.
• Medicinal Chemistry Research: Used in lead compound generation and structure-activity relationship (SAR) studies due to its modifiable carboxylic acid and heterocyclic amine functionalities.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new active ingredients for crop protection products.
• Chemical Biology Probes: Utilized in the design and creation of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes under cGMP conditions for clinical trial material production.

Basic Information

Product Name	2-(Pyrrolidin-1-Yl)Pyrimidine-4-Carboxylic Acid Hydrochloride
CAS No.	2361643-61-8
Molecular Formula	C9H12N3O2 • HCl
Molecular Weight	231.67 g/mol (Free base: 195.21 g/mol)
Synonyms	2-(1-Pyrrolidinyl)-4-pyrimidinecarboxylic acid hydrochloride; 4-Pyrimidinecarboxylic acid, 2-(1-pyrrolidinyl)-, hydrochloride; 2-Pyrrolidin-1-ylpyrimidine-4-carboxylic acid HCl; Pyrrolidin-1-yl-pyrimidine-4-carboxylic acid hydrochloride salt; 2361643-61-8; 2-(Pyrrolidin-1-yl)pyrimidine-4-carboxylic acid HCl salt
EINECS	Contact for details

Quality Control

Our 2-(Pyrrolidin-1-Yl)Pyrimidine-4-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete analytical data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.