Description

4(3H)-Quinazolinone, 7-[(1-Acetyl-4-Piperidinyl)Methoxy]-5-Fluoro-2-[[(Tetrahydro-2H-Pyran-4-Yl)Thio]Methyl]- is a sophisticated, high-purity pharmaceutical intermediate designed for advanced drug discovery and development. This compound is valued for its complex heterocyclic structure, which serves as a critical building block in the synthesis of novel therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors and other targeted small-molecule therapeutics.
• Oncology Research: Used in the development of experimental anti-cancer compounds due to its quinazolinone core, a common pharmacophore in oncology.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Development: Employed in the research and process development stages for new Active Pharmaceutical Ingredients (APIs).
• Biochemical Research: Utilized as a tool compound or a ligand in biochemical assays to study specific enzyme interactions and pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process scale-up services for the pharmaceutical industry.

Basic Information

Item	Detail
Product Name	4(3H)-Quinazolinone, 7-[(1-Acetyl-4-Piperidinyl)Methoxy]-5-Fluoro-2-[[(Tetrahydro-2H-Pyran-4-Yl)Thio]Methyl]-
CAS No.	2360853-16-1
Molecular Formula	C22H26FN3O4S
Molecular Weight	447.52 g/mol
Synonyms	7-[(1-Acetyl-4-piperidinyl)methoxy]-5-fluoro-2-[[(tetrahydro-2H-pyran-4-yl)thio]methyl]-4(3H)-quinazolinone; 5-Fluoro-7-[(1-acetylpiperidin-4-yl)methoxy]-2-[(tetrahydro-2H-pyran-4-ylthio)methyl]quinazolin-4(3H)-one; 2360853-16-1; Quinazolinone derivative, AC-123; CAS 2360853-16-1
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all critical specifications. We support development projects with GMP-grade material upon request, manufactured under controlled conditions suitable for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.