Description

Pyrimidine, 4,6-Dichloro-5-(1,3-Dioxolan-2-Yl)-2-Methyl- CAS NO 2359690-91-6 is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated pyrimidine core protected by a dioxolane group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in antiviral and oncology research, where precise molecular architecture is paramount. It serves as a key building block for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries, enabling the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel antiviral and anticancer drug candidates.
• Nucleoside/Nucleotide Analog Development: Used in research to create modified nucleosides that act as polymerase inhibitors or chain terminators.
• Agrochemical Research: Serves as a synthetic intermediate for developing new herbicides and fungicides with specific modes of action.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tagging agent in the study of enzyme mechanisms and protein interactions.
• Material Science Research: Investigated as a monomer or functional component for creating specialty polymers with tailored electronic or optical properties.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects and scale-up development under cGMP conditions.

Basic Information

Product Name	Pyrimidine, 4,6-Dichloro-5-(1,3-Dioxolan-2-Yl)-2-Methyl-
CAS No.	2359690-91-6
Molecular Formula	C8H8Cl2N2O2
Molecular Weight	235.07 g/mol
Synonyms	4,6-Dichloro-5-(1,3-dioxolan-2-yl)-2-methylpyrimidine; 2-Methyl-4,6-dichloro-5-(1,3-dioxolan-2-yl)pyrimidine; 5-(1,3-Dioxolan-2-yl)-4,6-dichloro-2-methylpyrimidine; 4,6-Dichloro-2-methyl-5-(1,3-dioxolan-2-yl)pyrimidine; CAS 2359690-91-6; 2-Methyl-4,6-dichloro-5-(2',2'-dimethyl-1,3-dioxolan-4'-yl)pyrimidine (related); Dichloro-dioxolanyl-methylpyrimidine intermediate
EINECS	Contact for details

Quality Control

Our Pyrimidine, 4,6-Dichloro-5-(1,3-Dioxolan-2-Yl)-2-Methyl- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the exacting standards required for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.