Description

Ethyl 5-Chloro-6-Fluoropyrazolo[1,5-A]Pyrimidine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidine class of heterocyclic compounds. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas such as oncology and inflammation.

Application

This specialized intermediate serves as a key precursor in sophisticated organic synthesis. Its primary applications include:

• Pharmaceutical Intermediate: Core building block for the synthesis of novel drug candidates, especially kinase inhibitors.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Chemical Biology: Employed as a molecular probe or scaffold in the study of biological pathways and target validation.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs for client-specific molecule development.
• Academic Research: Utilized in universities and research institutes for methodological studies in heterocyclic chemistry and medicinal chemistry programs.

Basic Information

Product Name	Ethyl 5-Chloro-6-Fluoropyrazolo[1,5-A]Pyrimidine-3-Carboxylate
CAS No.	2359650-50-1
Molecular Formula	C9H6ClFN4O2
Molecular Weight	256.62 g/mol
Synonyms	5-Chloro-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester; Ethyl 5-chloro-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxylate; 2359650-50-1; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 5-chloro-6-fluoro-, ethyl ester; 5-Chloro-6-fluoro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 5-Chloro-6-Fluoropyrazolo[1,5-A]Pyrimidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.