Description

5-Hexynoic Acid, 6-[2-(Methylsulfonyl)-5-Pyrimidinyl]- is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold that combines an alkyne-functionalized carboxylic acid with a methylsulfonyl pyrimidine moiety. This compound is of significant value for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel small molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing targeted therapies, particularly in oncology and other disease areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted small molecule therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its reactive alkyne and electron-withdrawing sulfone groups.
• Chemical Biology Probes: Serves as a precursor for developing activity-based probes or PROTACs (Proteolysis Targeting Chimeras) leveraging click chemistry via the alkyne handle.
• Agrochemical Research: Potential intermediate in the development of new active ingredients for crop protection products.
• Material Science: Can be investigated as a monomer or cross-linker for creating specialized polymers with unique thermal or mechanical properties.

Basic Information

Product Name	5-Hexynoic Acid, 6-[2-(Methylsulfonyl)-5-Pyrimidinyl]-
CAS No.	2356229-58-6
Molecular Formula	C12H14N2O4S
Molecular Weight	282.32 g/mol
Synonyms	6-[2-(Methylsulfonyl)pyrimidin-5-yl]hex-5-ynoic acid; 5-Hexynoic acid, 6-(2-(methylsulfonyl)-5-pyrimidinyl)-; 6-(2-Methanesulfonylpyrimidin-5-yl)hex-5-ynoic Acid; CAS 2356229-58-6; Methylsulfonyl-pyrimidine-hexynoic acid derivative; 5-Pyrimidinylhexynoic acid sulfone derivative
EINECS	Contact for details

Quality Control

Our 5-Hexynoic Acid, 6-[2-(Methylsulfonyl)-5-Pyrimidinyl]- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization, ensuring the material meets the exacting standards required for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.