Description

Fmoc-(S)-2-Amino-6-Phenylhexanoic Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected α-amino group and a lipophilic phenylhexyl side chain. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the precise incorporation of hydrophobic and structurally constrained residues. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, peptide-based diagnostics, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid for the automated synthesis of custom peptides with enhanced stability and bioavailability.
• Pharmaceutical Research: For constructing peptide libraries in drug discovery, particularly for targets involving protein-protein interactions.
• Peptidomimetic Development: Serves as a scaffold to create metabolically stable analogs of natural peptides for therapeutic applications.
• Bioconjugation: Used to introduce specific functional handles or hydrophobic tags onto peptides or proteins.
• Academic Research: In studies exploring peptide structure-activity relationships (SAR) and folding.
• API Intermediate: Potential use as a chiral intermediate in the synthesis of more complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Fmoc-(S)-2-Amino-6-Phenylhexanoic Acid
CAS No.	2350732-99-7
Molecular Formula	C27H27NO4
Molecular Weight	429.51 g/mol
Synonyms	Fmoc-(S)-2-Amino-6-phenylhexanoic acid; Fmoc-6-phenyl-L-norleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-6-phenyl-L-norleucine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-phenylhexanoic acid; Fmoc-L-6-Phenylnorleucine; Fmoc-Phenylhexylglycine; Fmoc-Phe(hex)-OH; Fmoc-2-Amino-6-phenylcaproic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-2-Amino-6-Phenylhexanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducible performance in your applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.