Description

(S)-Fmoc-2-Amino-5-(3,4-Dichlorophenyl)Pentanoic Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for the development of novel peptide-based pharmaceuticals and research tools, offering precise stereochemical control. It is primarily utilized by medicinal chemists and research scientists in pharmaceutical R&D, biotechnology, and academic institutions focused on peptide drug discovery and chemical biology.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptide sequences.
• Peptidomimetic Drug Discovery: Serves as a core scaffold for creating peptide analogs with enhanced metabolic stability, bioavailability, and target affinity.
• Chemical Biology Probes: Used to synthesize labeled or modified peptides for studying protein-protein interactions, enzyme mechanisms, and cellular pathways.
• GPCR Ligand Development: The dichlorophenyl moiety makes it valuable for constructing ligands targeting G-protein-coupled receptors (GPCRs), a major drug target class.
• Library Synthesis for High-Throughput Screening: Employed in the generation of diverse peptide libraries to identify new lead compounds with therapeutic potential.

Basic Information

Product Name	(S)-Fmoc-2-Amino-5-(3,4-Dichlorophenyl)Pentanoic Acid
CAS No.	2350690-24-1
Molecular Formula	C26H23Cl2NO4
Molecular Weight	484.37 g/mol
Synonyms	Fmoc-(S)-2-Amino-5-(3,4-dichlorophenyl)pentanoic acid; (S)-5-(3,4-Dichlorophenyl)-2-(((9H-fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid; N-α-Fmoc-3,4-dichloro-L-homophenylalanine; Fmoc-L-3,4-Dichlorohomophenylalanine; Fmoc-3,4-DiCl-homoPhe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,4-dichloro-L-homophenylalanine; Fmoc-3,4-DCPPA; Fmoc-DichlorohomoPhe-OH
EINECS	Contact for details

Quality Control

Our (S)-Fmoc-2-Amino-5-(3,4-Dichlorophenyl)Pentanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, and specifications can be aligned with client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.