Description

Boc-L-Phe(2-F,5-I)-Oh is a protected, halogenated derivative of the essential amino acid L-phenylalanine, specifically modified with fluorine and iodine substituents on the aromatic ring. This specialized building block is critical for the synthesis of complex peptides and peptidomimetics, enabling researchers to introduce unique steric, electronic, and metabolic properties into target molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutic agents, particularly in oncology and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel peptide-based drugs and bioactive compounds.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate halogenated phenylalanine residues, which can enhance binding affinity and metabolic stability.
• Proteomics Research: Acts as a tool compound for studying protein-protein interactions and enzyme mechanisms by acting as a site-specific probe.
• Chemical Biology: Employed in the design and synthesis of peptide libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Radiopharmaceutical Precursor: The iodine substituent makes it a potential precursor for labeling peptides with radioisotopes for diagnostic imaging (e.g., PET/SPECT) or targeted radiotherapy.
• Agrochemical Research: Can be used in the development of novel peptide-inspired bioactive agents for crop protection.

Basic Information

Product Name	Boc-L-Phe(2-F,5-I)-Oh
CAS No.	2350290-77-4
Molecular Formula	C20H21FINO5
Molecular Weight	501.19 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-3-(2-fluoro-5-iodophenyl)-L-alanine; Boc-2-Fluoro-5-iodo-L-phenylalanine; tert-Butyl (2S)-2-[(tert-butoxy)carbonylamino]-3-(2-fluoro-5-iodophenyl)propanoate; (S)-2-((tert-Butoxycarbonyl)amino)-3-(2-fluoro-5-iodophenyl)propanoic acid; Boc-L-2-Fluoro-5-iodophenylalanine; Boc-F(2-F,5-I)-OH
EINECS	Contact for details

Quality Control

Our Boc-L-Phe(2-F,5-I)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.