Description

3-Pyridinebutanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-6-Methyl-, (αs)- is a sophisticated, non-natural amino acid derivative featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group, designed for advanced peptide synthesis and medicinal chemistry research. This high-purity building block is critical for constructing complex peptide sequences with precise stereochemistry and enhanced stability. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on developing novel therapeutic peptides, peptidomimetics, and chemical probes. The compound's specific structure allows for the controlled introduction of a modified amino acid residue into target molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid derivative, it serves as a key monomer for the automated, stepwise assembly of custom peptides.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of novel peptide-based therapeutics, including enzyme inhibitors, receptor agonists/antagonists, and targeted drug conjugates.
• Peptidomimetic Design: Incorporated into synthetic scaffolds to mimic the structure and function of natural peptides while improving metabolic stability and bioavailability.
• Bioconjugation & Probe Development: Acts as a specialized linker or functional handle for labeling peptides with fluorophores, biotin, or other reporter molecules.
• Chemical Biology Research: Employed to study protein-protein interactions, enzyme mechanisms, and cellular signaling pathways using synthetic peptide tools.
• Process Development & Scale-Up: Sourced by CROs and CDMOs for the pilot-scale and commercial-scale production of peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3-Pyridinebutanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-6-Methyl-, (αs)-
CAS No.	2350266-21-4
Molecular Formula	C25H24N2O4
Molecular Weight	416.47 g/mol
Synonyms	Fmoc-(αS)-α-amino-6-methyl-3-pyridinebutanoic acid; (αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-6-methyl-3-pyridinebutanoic acid; Fmoc-6-Me-3-PyAla-OH; Fmoc-3-(6-methylpyridin-3-yl)-L-alanine; Fmoc-β-(6-methyl-3-pyridyl)-L-alanine; N-α-Fmoc-3-(6-methyl-3-pyridinyl)-L-alanine; A non-natural Fmoc-protected amino acid
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, essential for sensitive synthetic applications. Our standard grade meets specifications suitable for research and development use, with Certificates of Analysis (COA) provided for each lot, detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profiles. We adhere to cGMP principles where applicable, and specifications can be aligned with client requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and performance. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.