Description

4-Morpholinepentanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is a specialized Fmoc-protected amino acid derivative, a critical building block in modern peptide synthesis. Its value lies in enabling the precise and efficient construction of complex peptide sequences, particularly those requiring the morpholine moiety for specific bioactivity or structural properties. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require reliable, high-quality reagents for solid-phase and solution-phase peptide synthesis.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key monomer for the automated, stepwise assembly of peptides on resin.
• Pharmaceutical Research & Development: Used in the synthesis of novel therapeutic peptide candidates, especially those targeting GPCRs or requiring enhanced pharmacokinetic properties.
• Bioconjugation and Probe Development: Incorporation of the morpholine group into peptides for creating targeted imaging agents, drug conjugates, or biochemical probes.
• Combinatorial Chemistry Libraries: A valuable building block for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Material Science: Potential use in synthesizing peptide-based polymers or biomaterials where the morpholine functionality imparts specific solubility or interactive properties.

Basic Information

Product Name	4-Morpholinepentanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)-
CAS No.	2350138-22-4
Molecular Formula	C24H28N2O5
Molecular Weight	424.49 g/mol
Synonyms	Fmoc-4-morpholine-DL-norvaline; Fmoc-DL-4-Morpholinonorvaline; (αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-morpholinepentanoic acid; N-α-Fmoc-4-morpholine-DL-norvaline; Fmoc-4-Morpholinonorvaline-OH; 4-Morpholine-DL-norvaline, N-α-Fmoc-; Fmoc-(4-morpholinyl)-DL-norvaline; Building block for peptide synthesis (CAS 2350138-22-4)
EINECS	Contact for details

Quality Control

Our 4-Morpholinepentanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. All materials undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.