Description

Fmoc-3-Ethynylphe CAS NO 2350099-77-1 is a high-purity, protected amino acid derivative featuring an ethynyl side chain, serving as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the site-specific introduction of alkyne functional groups into peptide sequences, which are essential for subsequent bioorthogonal conjugation reactions like click chemistry. This compound is indispensable for researchers and manufacturers in pharmaceutical R&D, chemical biology, and proteomics who require precise structural modification and labeling of bioactive peptides and proteins.

Application

• Peptide Drug Discovery: Incorporation of alkyne handles into peptide backbones for the development of novel therapeutics, including peptide-drug conjugates (PDCs).
• Chemical Biology Probes: Synthesis of activity-based probes and affinity tags for target identification and protein interaction studies via CuAAC or SPAAC click reactions.
• Bioconjugation & Labeling: Facilitating the site-specific attachment of fluorophores, biotin, polyethylene glycol (PEG), or other functional moieties to peptides.
• Material Science & Surface Functionalization: Creating peptide-based biomaterials, hydrogels, or functionalized surfaces for biosensing and tissue engineering applications.
• Library Synthesis: Used in combinatorial chemistry for generating diverse peptide libraries with "clickable" sites for high-throughput screening.

Basic Information

Product Name	Fmoc-3-Ethynylphe CAS NO 2350099-77-1
CAS No.	2350099-77-1
Molecular Formula	C₂₆H₂₁NO₄
Molecular Weight	411.45 g/mol
Synonyms	Fmoc-3-Ethynyl-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-ethynyl-L-phenylalanine; Fmoc-3-Ethynylphenylalanine; Fmoc-L-3-EthynylPhe-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-ethynylphenyl)propanoic acid; Fmoc-3-Ethynylphe-OH; Fmoc-3-Ethynyl-Phe; Protected 3-Ethynylphenylalanine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-3-Ethynylphe CAS NO 2350099-77-1 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and MS. Our quality commitment aligns with standards relevant to pharmaceutical intermediates and advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.