Description

Fmoc-(S)-2-Amino-5-(4-Fluorophenyl)Pentanoicacid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound matters as a critical building block for introducing the (S)-2-amino-5-(4-fluorophenyl)pentanoic acid moiety with an orthogonal Fmoc protecting group, enabling precise control in solid-phase peptide synthesis (SPPS). It is essential for researchers and manufacturers in pharmaceutical R&D, particularly those developing novel peptide-based therapeutics, diagnostic agents, and biochemical probes where structural precision is paramount.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Specifically used in Fmoc-based solid-phase peptide synthesis (SPPS) for the controlled incorporation of a fluorinated phenylalanine analogue into peptide chains.
• Biochemical Research: Employed in the study of protein-protein interactions, enzyme substrates, and receptor ligands where fluorinated amino acids are used as probes.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to investigate the effect of fluorination on peptide stability, bioavailability, and binding affinity.
• Labeled Compound Synthesis: Serves as a precursor for synthesizing isotopically labeled peptides for mass spectrometry and metabolic studies.

Basic Information

Product Name	Fmoc-(S)-2-Amino-5-(4-Fluorophenyl)Pentanoicacid
CAS No.	2349948-37-2
Molecular Formula	C₂₆H₂₄FNO₄
Molecular Weight	433.47 g/mol
Synonyms	Fmoc-(S)-2-Amino-5-(4-fluorophenyl)pentanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-fluoro-L-homophenylalanine; Fmoc-4-Fluoro-L-homophenylalanine; Fmoc-L-4-Fluorohomophe; N-α-Fmoc-4-fluoro-L-homophenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-5-(4-fluorophenyl)pentanoic acid; Fmoc-4-F-homoPhe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-2-Amino-5-(4-Fluorophenyl)Pentanoicacid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot undergoes comprehensive analytical testing including HPLC, NMR, and MS to verify identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.