Description

(2S)-5-(3,5-Difluorophenyl)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Pentanoic Acid is a sophisticated, non-natural amino acid derivative featuring a fluorenylmethyloxycarbonyl (Fmoc) protecting group and a difluorophenyl side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise construction of complex peptides and peptidomimetics. It is essential for researchers and manufacturers in pharmaceutical R&D and biotechnology who require high-purity, structurally defined intermediates for developing novel therapeutics, including protease inhibitors and receptor-targeting molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key monomer for the automated, sequential assembly of custom peptide sequences.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for peptides targeting metabolic and neurological disorders.
• Peptidomimetic Design: The difluorophenyl moiety provides enhanced metabolic stability and binding affinity, making it valuable for creating peptide-like drug candidates with improved pharmacokinetic properties.
• Bioconjugation and Probe Development: Acts as a precursor for synthesizing fluorescent or affinity-labeled peptides used in biochemical assays and diagnostic tools.
• Academic and Contract Research: A vital reagent for universities and CROs (Contract Research Organizations) exploring protein-protein interactions and new bioactive peptides.
• Process Development & Scale-Up: Supports process chemistry teams in optimizing synthetic routes for peptide-based drugs from milligram to kilogram scale.

Basic Information

Item	Details
Product Name	(2S)-5-(3,5-Difluorophenyl)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Pentanoic Acid
CAS No.	2349727-63-3
Molecular Formula	C26H23F2NO4
Molecular Weight	451.46 g/mol
Synonyms	Fmoc-D-2,4-difluorophenylalanine-OH; Fmoc-3,5-Difluoro-D-phenylalanine; Fmoc-D-3,5-Dif-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,5-difluoro-D-phenylalanine; (2R)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(3,5-difluorophenyl)propanoic acid (enantiomer); Fmoc-3,5-Difluoro-D-Phe; CAS 2349727-63-3; Amino acid Fmoc derivative
EINECS	Contact for details

Quality Control

Our production of this advanced amino acid derivative adheres to strict quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive peptide synthesis. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We employ analytical methods including HPLC, NMR, and mass spectrometry to verify identity and meet the stringent requirements of pharmaceutical R&D and GMP environments. Certificates are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.