Description

L-Norvaline, 5-(1,1-Dimethylethoxy)-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]- is a sophisticated, protected amino acid derivative designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring high-purity, structurally defined building blocks for complex molecule assembly. It is primarily utilized in the pharmaceutical and biotechnology sectors for the synthesis of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a crucial building block for the controlled, sequential assembly of custom peptides.
• Pharmaceutical Intermediate: Used in the research and development of new therapeutic agents, particularly in creating molecules with specific biological activity.
• Peptidomimetic Design: Essential for constructing non-peptide compounds that mimic the structure and function of natural peptides, improving metabolic stability and bioavailability.
• Bioconjugation and Labeling: The reactive handles allow for site-specific modification of proteins or other biomolecules for diagnostic or therapeutic purposes.
• Chemical Biology Research: Employed in probing enzyme mechanisms, protein-protein interactions, and cellular pathways using designed peptide probes.
• Academic and R&D Laboratories: A key reagent for synthetic chemistry research focused on amino acid chemistry and novel synthetic methodologies.

Basic Information

Product Name	L-Norvaline, 5-(1,1-Dimethylethoxy)-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-
CAS No.	2349713-29-5
Molecular Formula	C24H29NO5
Molecular Weight	411.49 g/mol
Synonyms	Fmoc-Norvaline(OtBu); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-(1,1-dimethylethoxy)-L-norvaline; Fmoc-L-Norvaline(OtBu)-OH; Nα-Fmoc-Nδ-tert-butoxy-L-norvaline; Fmoc-Nva(OtBu)-OH; (2S)-5-[(2-Methylpropan-2-yl)oxy]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid; Fmoc-Norvaline(tert-butyl ether)
EINECS	Contact for details

Quality Control

Our production of this advanced synthetic intermediate adheres to strict quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural integrity and purity. A comprehensive Certificate of Analysis (COA) detailing identity, assay, chiral purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.