Description

Fmoc-L-3-Cyanohomophenylalanine is a non-natural, side-chain modified amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is engineered to introduce a cyano-functionalized aromatic side chain into peptide sequences, enabling the study of structure-activity relationships and the development of novel bioactive molecules. It is an essential building block for researchers and manufacturers in pharmaceutical R&D, biotechnology, and advanced materials science who require high-purity, specialized amino acids for peptide-based drug discovery and chemical biology.

Application

• Peptide Drug Discovery: Incorporation into peptide sequences to modulate bioactivity, stability, and receptor binding affinity.
• Chemical Biology Probes: Synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Structure-Activity Relationship (SAR) Studies: Systematic modification of peptide structures to understand the role of aromatic and polar functional groups.
• Novel Biomaterial Synthesis: Building block for creating functionalized peptides used in hydrogels, coatings, and delivery systems.
• Antibody-Drug Conjugate (ADC) Linker Research: Potential use in constructing specialized linkers or payloads due to its functionalized side chain.
• Peptidomimetic Design: Core component for developing peptide-like molecules with enhanced metabolic stability and pharmacological properties.

Basic Information

Product Name	Fmoc-L-3-Cyanohomophenylalanine
CAS No.	2349706-36-9
Molecular Formula	C₂₆H₂₂N₂O₄
Molecular Weight	426.47 g/mol
Synonyms	Fmoc-3-Cyano-L-homophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-cyano-L-homophenylalanine; Fmoc-L-β-homo-3-cyanophenylalanine; Fmoc-3-CN-Hph-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-4-(3-cyanophenyl)butanoic acid; N-α-Fmoc-3-cyano-L-homophenylalanine; Fmoc-L-3-CN-HomoPhe
EINECS	Contact for details

Quality Control

Every batch of Fmoc-L-3-Cyanohomophenylalanine is produced and tested under strict quality management systems. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. A Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profiles is provided with each shipment to ensure it meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.