Description

Cyclopentanepentanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is a high-purity, non-natural amino acid derivative featuring a cyclopentane backbone and Fmoc-protected amine functionality. This compound is critical for advanced research and development in pharmaceutical chemistry, particularly in the synthesis of novel peptide-based therapeutics and bioactive molecules. It serves as a sophisticated building block for medicinal chemists and researchers in biotechnology and fine chemical synthesis who require precise molecular architecture and reliable purity for their most demanding projects.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected unnatural amino acid, it is a key intermediate for introducing constrained, cyclopentane-based structures into peptide chains to modulate bioactivity and stability.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of new drug candidates, particularly for creating peptidomimetics and conformationally restricted analogs to improve pharmacokinetic properties.
• Bioconjugation and Probe Development: Employed in the synthesis of labeled peptides or protein conjugates for diagnostic assays, imaging probes, and targeted delivery systems.
• Chemical Biology Research: Serves as a tool compound for studying protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR) in academic and industrial R&D settings.
• Fine Chemical and Custom Synthesis: A valuable starting material or intermediate for contract research organizations (CROs) and CDMOs producing specialized, non-commercial compounds for client projects.

Basic Information

Product Name	Cyclopentanepentanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)-
CAS No.	2349606-67-1
Molecular Formula	C25H27NO5
Molecular Weight	421.49 g/mol
Synonyms	Fmoc-(αS)-α-amino-1-cyclopentanepentanoic acid; (αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-1-cyclopentanepentanoic acid; Fmoc-Acp5-OH (Acp5 = 1-aminocyclopentanepentanoic acid); (S)-Fmoc-1-amino-1-cyclopentanepentanoic acid; Unnatural Fmoc-amino acid; Fmoc-protected cyclopentane amino acid; CAS 2349606-67-1
EINECS	Contact for details

Quality Control

Our Cyclopentanepentanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive spectroscopic identification (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports critical applications in pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.