Description

(2S)-4-(3-Ethynylphenyl)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Butanoic Acid is a sophisticated, non-natural amino acid derivative featuring a fluorenylmethyloxycarbonyl (Fmoc) protecting group and an ethynylphenyl side chain. This compound is of critical importance in advanced peptide synthesis and pharmaceutical research, serving as a key building block for constructing complex molecules with specific structural and functional properties. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the discovery and development of novel therapeutic agents and bioactive peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the sequential assembly of custom peptides in automated synthesizers.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of new drug candidates, particularly those targeting protein-protein interactions.
• Bioconjugation and Click Chemistry: The alkyne (ethynyl) functional group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling, tagging, and linking biomolecules.
• Peptidomimetic Design: Used to incorporate non-natural, constrained amino acid motifs into peptide backbones to enhance stability, bioavailability, and binding affinity.
• Chemical Biology Probes: Essential for creating tool compounds and probes to study enzyme function, receptor binding, and cellular pathways.
• High-Purity Reference Standard: Supplied as a characterized compound for analytical method development and quality control in peptide API manufacturing.

Basic Information

Product Name	(2S)-4-(3-Ethynylphenyl)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Butanoic Acid
CAS No.	2349596-60-5
Molecular Formula	C27H23NO4
Molecular Weight	425.48 g/mol
Synonyms	Fmoc-(S)-3-(3-ethynylphenyl)-alanine; Fmoc-3-(3-Ethynylphenyl)-D-alanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-ethynylphenyl)propanoic acid; Fmoc-D-3-(3-Ethynylphenyl)Ala-OH; Fmoc-D-3-(3-Ethynylphenyl)alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-ethynylphenyl)-D-alanine; BOC Sciences Brand Name: BBL-BB-015-0036; CAS 2349596-60-5
EINECS	Contact for details

Quality Control

Every batch of (2S)-4-(3-Ethynylphenyl)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Butanoic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical research and peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.