Description

L-Allothreonine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-O,3-Dimethyl- is a protected amino acid derivative, specifically a Fmoc-protected allothreonine analog. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of modified threonine residues into peptide chains. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and the production of complex peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of peptides, particularly those requiring the L-allothreonine isomer.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, hormone analogs, and other bioactive peptides for preclinical studies.
• Proteomics and Biochemical Research: Employed to create custom peptides for antibody production, enzyme substrate studies, and protein-protein interaction analysis.
• Synthesis of Modified Peptides: Facilitates the incorporation of O-methylated and other side-chain modified amino acids to study structure-activity relationships (SAR).
• Combinatorial Chemistry Libraries: Serves as a valuable building block for generating diverse peptide libraries for high-throughput screening.

Basic Information

Product Name	L-Allothreonine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-O,3-Dimethyl-
CAS No.	2349454-08-4
Molecular Formula	C22H23NO5
Molecular Weight	381.42 g/mol
Synonyms	Fmoc-L-allo-Thr(Me)-OH; Fmoc-L-allothreonine(O-methyl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-allothreonine; (2S,3R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methoxybutanoic acid; Fmoc-allo-Thr(Me)-OH; Fmoc-L-Thr(Me)-OH (alloisomer); Protected L-allothreonine derivative; Fmoc-amino acid building block
EINECS	Contact for details

Quality Control

Our Fmoc-protected amino acid derivatives are manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and specific impurity profiles are provided to ensure compliance with research and cGMP starting material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.