Description

D-Norvaline, 5-(1,1-Dimethylethoxy)-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]- is a sophisticated, non-proteinogenic amino acid derivative, specifically engineered for advanced pharmaceutical research and peptide synthesis. This compound is a critical building block for medicinal chemists, offering a protected side chain that enables precise, multi-step synthetic strategies. It is primarily utilized in the development of novel peptide-based therapeutics, active pharmaceutical ingredients (APIs), and as a key intermediate in complex organic synthesis for the life sciences sector.

Application

• Peptide Synthesis Intermediate: A crucial protected amino acid derivative for solid-phase and solution-phase peptide synthesis (SPPS), enabling the controlled incorporation of D-norvaline into peptide chains.
• Pharmaceutical Research & Development: Serves as a key building block in the discovery and development of novel peptide-based drugs, prodrugs, and bioactive molecules.
• API (Active Pharmaceutical Ingredient) Manufacturing: Used as a high-purity intermediate in the multi-step synthesis of complex target molecules for clinical and commercial pharmaceutical production.
• Medicinal Chemistry & SAR Studies: Facilitates structure-activity relationship (SAR) studies by providing a specific stereochemical and functionalized amino acid scaffold for molecular optimization.
• Bioconjugation & Chemical Biology: Employed in the synthesis of labeled peptides, peptide-drug conjugates, and other tools for biochemical and diagnostic applications.
• Academic & Industrial Research: A valuable reagent for universities and R&D centers focused on organic synthesis, asymmetric synthesis, and amino acid chemistry.

Basic Information

Product Name	D-Norvaline, 5-(1,1-Dimethylethoxy)-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-
CAS No.	2349431-74-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Fmoc-D-Norvaline(tert-butyl ester); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-norvaline 5-(1,1-dimethylethyl) ester; Fmoc-D-Nva(OtBu)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid tert-butyl ester; Fmoc-D-2-Aminopentanoic acid tert-butyl ester; D-Norvaline, N-Fmoc, O-tert-butyl; Boc-D-Norvaline-Fmoc derivative; Protected D-Norvaline Fmoc derivative
EINECS	Contact for details

Quality Control

Our D-Norvaline, 5-(1,1-Dimethylethoxy)-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]- is produced under strict quality management systems to ensure the high purity and consistency required for pharmaceutical R&D. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.