Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-[2-Fluoro-4-(Trifluoromethyl)Phenyl]Propanoic Acid is a high-purity, non-natural amino acid derivative designed for advanced pharmaceutical research and development. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a fluorinated aromatic side chain into target peptide sequences. It is essential for medicinal chemists and peptide scientists working on novel therapeutics, particularly in oncology and CNS drug discovery, where its unique fluorine and trifluoromethyl motifs can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated synthesis of complex peptides and peptidomimetics.
• Medicinal Chemistry & Drug Discovery: Used to introduce fluorinated aromatic groups into lead compounds to optimize their pharmacokinetic and pharmacodynamic properties.
• Pharmaceutical Intermediate: Serves as a key chiral intermediate in the synthesis of active pharmaceutical ingredients (APIs) targeting specific receptors.
• Bioconjugation & Probe Development: Facilitates the creation of labeled peptides for diagnostic imaging, biomarker research, and biochemical assays.
• Chemical Biology Research: Enables the study of protein-protein interactions and enzyme mechanisms by incorporating non-natural amino acids into proteins.
• Process Development & Scale-up: Supports the transition from laboratory-scale research to commercial manufacturing of peptide-based drugs.

Basic Information

Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-[2-Fluoro-4-(Trifluoromethyl)Phenyl]Propanoic Acid
CAS No.	2349352-61-8
Molecular Formula	C25H19F4NO4
Molecular Weight	473.42 g/mol
Synonyms	Fmoc-2-Fluoro-4-(trifluoromethyl)-L-phenylalanine; Fmoc-L-2-F-4-CF3-Phe-OH; Fmoc-2-F-4-(CF3)-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-fluoro-4-(trifluoromethyl)-L-phenylalanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-fluoro-4-(trifluoromethyl)phenyl)propanoic acid; Fmoc-2-F-4-TFM-Phe; Fmoc-(2-F,4-CF3)Phe-OH; Fmoc-2-Fluoro-4-trifluoromethylphenylalanine
EINECS	Contact for details

Quality Control

Our production of this advanced amino acid derivative adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We employ state-of-the-art analytical techniques including HPLC, NMR, and Mass Spectrometry to verify identity and purity, ensuring the material meets the exacting standards required for pharmaceutical R&D and GLP/GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.