Description

n-Fmoc-D-Homophe(2-F,3-Cl)-Oh is a non-natural, fluorinated and chlorinated amino acid derivative designed for advanced peptide synthesis. This compound is engineered to introduce specific halogenated side-chain modifications, enhancing the metabolic stability, lipophilicity, and binding affinity of therapeutic peptides. It is an essential building block for research and development in pharmaceutical discovery, particularly for creating novel peptide-based drugs targeting GPCRs, enzymes, and other biological pathways. The precise stereochemistry and protective group strategy ensure high coupling efficiency and purity in solid-phase peptide synthesis (SPPS).

Application

• Pharmaceutical Research & Development: A critical intermediate in the synthesis of novel peptide therapeutics, including hormone analogs, enzyme inhibitors, and antimicrobial peptides.
• Peptidomimetic Design: Used to create stable peptidomimetics by incorporating halogenated aromatic side chains that resist enzymatic degradation.
• Structure-Activity Relationship (SAR) Studies: Enables medicinal chemists to probe the impact of specific halogen substitutions (Fluorine and Chlorine) on peptide bioactivity and pharmacokinetics.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected, Fmoc-based amino acid building block for automated and manual peptide assembly.
• Chemical Biology Probes: Utilized in the development of labeled or tagged peptides for imaging, target identification, and mechanistic studies.
• API Intermediate Manufacturing: A potential key raw material in the cGMP production of Active Pharmaceutical Ingredients (APIs) for clinical trials.

Basic Information

Product Name	n-Fmoc-D-Homophe(2-F,3-Cl)-Oh
CAS No.	2349350-51-0
Molecular Formula	C26H23ClFNO4
Molecular Weight	467.92 g/mol
Synonyms	Fmoc-D-3-(2-Fluoro-3-chlorophenyl)homoalanine; Fmoc-D-(2-F,3-Cl)-Homophenylalanine-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-fluoro-3-chlorophenyl)-D-homoalanine; D-Fmoc-homo-Phe(2-F,3-Cl)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-fluoro-3-chlorophenyl)butanoic acid; Fmoc-D-Hph(2-F,3-Cl)-OH; Fmoc-D-3-(2-Fluoro-3-chlorobenzyl)alanine; Protected Halogenated Amino Acid Building Block
EINECS	Contact for details

Quality Control

Every batch of n-Fmoc-D-Homophe(2-F,3-Cl)-Oh is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive pharmaceutical research. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as chiral purity, chemical purity (HPLC), and residual solvent content. Our quality protocols are designed to support regulatory filings for drug discovery and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.