Description

2H-Pyran-4-Butanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Tetrahydro-, (αs)- is a sophisticated, high-purity chemical building block designed for advanced synthetic applications. Its core value lies in its role as a protected amino acid derivative, offering precise stereochemistry and functional group compatibility for complex molecular assembly. This compound is essential for researchers and process chemists in the pharmaceutical and biotechnology sectors, particularly in the development of novel peptide-based therapeutics, peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetic drug candidates.
• Proteomics Research: Used in the design and synthesis of custom peptides for studying protein-protein interactions, enzyme activity, and cellular signaling pathways.
• Bioconjugation: Serves as a specialized linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or reporter tags in diagnostic assay development.
• Medicinal Chemistry: Enables the exploration of structure-activity relationships (SAR) by incorporating modified amino acid structures into lead optimization programs.
• Academic & Institutional R&D: Provides a reliable, high-quality reagent for universities and research institutes focused on synthetic organic chemistry and chemical biology.
• Process Development: Supports scale-up and route scouting for the commercial manufacturing of peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2H-Pyran-4-Butanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Tetrahydro-, (αs)-
CAS No.	2348350-11-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]tetrahydro-2H-pyran-4-butanoic acid; Fmoc-(S)-Amino-4-(tetrahydro-2H-pyran-4-yl)butanoic acid; Fmoc-Ahppa-OH (tetrahydropyranyl variant); Fmoc-protected non-natural amino acid; 4-(Tetrahydro-2H-pyran-4-yl)-L-2-aminobutanoic acid Fmoc derivative; Protected amino acid building block; CAS 2348350-11-6
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing support. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We support compliance with ICH guidelines for impurities and stability, providing the traceability and documentation required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions (e.g., nitrogen or argon atmosphere) when possible to maintain stability and prevent degradation. Keep the container tightly sealed after each use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.