Description

(2S)-4-(4-Cyanophenyl)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Butanoic Acid is a high-purity, non-natural amino acid derivative featuring a protected amine group (Fmoc) and a cyano-functionalized aromatic side chain. This compound is critical for advanced peptide synthesis, enabling the precise incorporation of unique structural motifs into complex biomolecules. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the development of novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the controlled assembly of custom peptide sequences.
• Peptidomimetic Drug Discovery: For introducing a rigid, polar cyano-phenyl moiety to modulate the bioavailability and target binding affinity of peptide-based drug candidates.
• Chemical Biology Probes: In the synthesis of labeled or modified peptides used to study protein-protein interactions and enzyme mechanisms.
• API Intermediate Manufacturing: Serves as a sophisticated intermediate in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Combinatorial Chemistry Libraries: Used to create diverse libraries of compounds for high-throughput screening in drug discovery programs.
• Linker & Conjugate Chemistry: The carboxylic acid and cyano groups provide handles for further conjugation to other molecules, polymers, or solid supports.

Basic Information

Product Name	(2S)-4-(4-Cyanophenyl)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Butanoic Acid
CAS No.	2348310-52-9
Molecular Formula	C26H22N2O4
Molecular Weight	426.47 g/mol
Synonyms	Fmoc-(S)-4-Cyanophenylalanine-OH; Fmoc-S-4-Cyanophe-OH; Fmoc-4-CN-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-cyano-L-phenylalanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(4-cyanophenyl)propanoic Acid; Fmoc-L-4-Cyanophenylalanine; Fmoc-Phe(4-CN)-OH
EINECS	Contact for details

Quality Control

Our (2S)-4-(4-Cyanophenyl)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Butanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity (typically ≥98% by HPLC), chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.