Description

((3Ar,4R,6R,6Ar)-2,2-Dimethyl-6-(2-Oxo-4-(1H-1,2,4-Triazol-1-Yl)Pyrimidin-1(2H)-Yl)Tetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)Methyl Isobutyrate is a sophisticated nucleoside analog derivative, representing a high-value intermediate in modern pharmaceutical synthesis. This compound is engineered to serve as a key building block for the development of novel antiviral and anticancer therapeutics, offering precise stereochemical control for targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the discovery and production of next-generation nucleoside-based drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral agents, particularly those targeting viral polymerases.
• Anticancer Drug Research: Used as a building block for developing nucleoside analogs that inhibit cancer cell proliferation.
• Biochemical Research: Serves as a tool compound in enzymatic studies and mechanism-of-action research for nucleotide metabolism.
• Prodrug Development: The isobutyrate moiety can be leveraged in prodrug strategies to enhance the bioavailability of active nucleoside components.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific drug discovery programs.

Basic Information

Item	Details
Product Name	((3Ar,4R,6R,6Ar)-2,2-Dimethyl-6-(2-Oxo-4-(1H-1,2,4-Triazol-1-Yl)Pyrimidin-1(2H)-Yl)Tetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)Methyl Isobutyrate
CAS No.	2346620-54-8
Molecular Formula	C19H23N5O6
Molecular Weight	417.42 g/mol
Synonyms	Isobutyric acid ((3aR,4R,6R,6aR)-2,2-dimethyl-6-(2-oxo-4-(1H-1,2,4-triazol-1-yl)pyrimidin-1(2H)-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl ester; 1-((3aR,4R,6R,6aR)-4-((Isobutyryloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-6-yl)-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one; Nucleoside Triazole Pyrimidinone Isobutyrate Ester; Advanced Nucleoside Intermediate 2346620-54-8
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality management systems. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment, supporting regulatory filings and GMP-grade manufacturing where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which may affect stability and handling properties. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.