Description

Vh 032-Linker 8 is a specialized chemical building block designed for advanced synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates for complex molecular assembly. It is primarily utilized in the pharmaceutical and biotechnology sectors for applications such as proteolysis-targeting chimera (PROTAC) development, antibody-drug conjugate (ADC) linker chemistry, and other cutting-edge therapeutic modalities.

Application

• PROTAC (Proteolysis-Targeting Chimera) Synthesis: Serves as a key linker component connecting E3 ligase ligands to target protein binders.
• Antibody-Drug Conjugate (ADC) Development: Used as a cleavable or non-cleavable linker to attach cytotoxic payloads to monoclonal antibodies.
• Bifunctional Molecule Construction: Enables the creation of molecules with two distinct functional moieties for targeted therapies.
• Chemical Biology Probes: Facilitates the synthesis of tools for studying protein function and interaction within cells.
• Peptide and Protein Conjugation: Acts as a cross-linking agent for modifying biomolecules.
• Materials Science: Potential use in creating functionalized surfaces or polymers with specific bioactive properties.

Basic Information

Product Name	Vh 032-Linker 8
CAS No.	2341796-77-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	VH-032-Linker 8; VH032 Linker 8; VHL Ligand-Linker Conjugate 8; (S,R,S)-AHPC-PEG3-C6-NH2; E3 Ligase Ligand-Linker Conjugate 8; VHL-based PROTAC Linker; VH-032-PEG3-C6-amine; VHL Recruiting Molecule 8
EINECS	Contact for details

Quality Control

Our Vh 032-Linker 8 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.