Description

Pomalidomide-Peg4-Nh2 Hydrochloride is a high-purity, functionalized derivative of the immunomodulatory agent pomalidomide, designed for advanced pharmaceutical research and development. This compound is a critical building block for the synthesis of antibody-drug conjugates (ADCs) and targeted therapeutics, enabling precise drug delivery. It is primarily utilized by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in oncology drug discovery and the development of next-generation bioconjugates.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Synthesis: Serves as a key intermediate for constructing ADCs, where the PEG4 spacer enhances solubility and the amine group allows for site-specific conjugation to antibodies.
• Targeted Cancer Therapy Development: Used in research to create novel prodrugs and targeted molecules that deliver pomalidomide's anti-cancer and immunomodulatory effects directly to tumor cells.
• PROTAC® (Proteolysis Targeting Chimera) Molecule Construction: Acts as a ligand component in the design of bifunctional molecules aimed at degrading specific disease-causing proteins.
• Bioconjugation and Chemical Biology Research: Employed as a versatile reagent for labeling proteins, peptides, and other biomolecules to study biological pathways and drug mechanisms of action.
• Pharmaceutical Intermediate: Used in the cGMP-compliant synthesis of investigational new drugs (INDs) and clinical trial materials.

Basic Information

Product Name	Pomalidomide-Peg4-Nh2 Hydrochloride
CAS No.	2331259-45-9
Molecular Formula	C31H44ClN5O10
Molecular Weight	682.16 g/mol
Synonyms	Pomalidomide-PEG4-amine hydrochloride; 4-Amino-PEG4-Pomalidomide HCl; Pomalidomide-PEG4-NH2•HCl; 1-Oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline-3-PEG4-amine hydrochloride; CC-4047-PEG4-NH2 HCl; (S)-3-(4-Amino-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione PEG4 amine hydrochloride; Amino-PEG4-C2-Pomalidomide hydrochloride
EINECS	Contact for details

Quality Control

Our Pomalidomide-Peg4-Nh2 Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for advanced pharmaceutical intermediates, with analytical methods including HPLC, NMR, and mass spectrometry to verify high chemical purity and correct structure.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	97.0% - 103.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.