Description

3-Azetidinecarboxylic Acid, 1-(Fluorosulfonyl)- is a high-value, fluorosulfonyl-functionalized azetidine derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, combining a strained four-membered azetidine ring with a reactive fluorosulfonyl group, makes it an indispensable reagent for introducing sulfonamide motifs and facilitating ring-opening reactions under mild conditions. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel bioactive molecules and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key synthon for constructing sulfonamide-based active pharmaceutical ingredients (APIs), particularly in protease inhibitor and kinase inhibitor drug discovery programs.
• Agrochemical Synthesis: Used in the development of new herbicides and fungicides, where the sulfonyl moiety can enhance biological activity and environmental stability.
• Material Science Precursor: Acts as a monomer or cross-linking agent for synthesizing specialty polymers with unique thermal or chemical resistance properties.
• Bioconjugation Chemistry: Employed as a reactive handle for labeling biomolecules (proteins, peptides) due to the electrophilic nature of the fluorosulfonyl group.
• Chemical Biology Probes: Utilized in the design of activity-based probes (ABPs) to study enzyme function and mechanism in complex biological systems.
• Ligand Development for Catalysis: Serves as a precursor for creating novel chiral ligands and organocatalysts containing the azetidine scaffold.

Basic Information

Item	Details
Product Name	3-Azetidinecarboxylic Acid, 1-(Fluorosulfonyl)-
CAS No.	2309463-31-6
Molecular Formula	C4H6FNO4S
Molecular Weight	183.16 g/mol
Synonyms	1-(Fluorosulfonyl)azetidine-3-carboxylic acid; Azetidine-3-carboxylic acid, 1-(fluorosulfonyl)-; Fluorosulfonyl azetidine-3-carboxylic acid; 1-Fluorosulfonylazetidine-3-carboxylic acid; 3-Carboxy-1-fluorosulfonylazetidine; FS-Aze-OH
EINECS	Contact for details

Quality Control

Every batch of 3-Azetidinecarboxylic Acid, 1-(Fluorosulfonyl)- is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) and allowed to reach room temperature before opening to prevent moisture ingress. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.