Description

Fmoc-Gly(Cycloheptyl)-Oh is a specialized, protected amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters because it enables the precise incorporation of the unique cycloheptylglycine residue, a non-proteinogenic amino acid that can impart enhanced metabolic stability and conformational rigidity to therapeutic peptides. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel peptide-based drugs, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Peptide Synthesis: A key intermediate for the synthesis of peptide drug candidates containing the cycloheptylglycine moiety.
• Research & Development: Used in academic and industrial labs to study structure-activity relationships (SAR) and to create peptide libraries for screening.
• Bioconjugation: Serves as a building block for creating peptide-based conjugates for targeted drug delivery or diagnostic imaging.
• GPCR Ligand Development: Incorporation into peptides targeting G-protein-coupled receptors (GPCRs) where the bulky, lipophilic side chain can influence binding affinity and selectivity.
• Enzyme Inhibitor Design: Used in the synthesis of peptide-based enzyme inhibitors where the cycloheptyl group can occupy specific hydrophobic pockets.
• Production of Custom Peptides: Essential raw material for CROs and CDMOs offering custom peptide synthesis services for clients.

Basic Information

Item	Details
Product Name	Fmoc-Gly(Cycloheptyl)-Oh
CAS No.	2304413-61-2
Molecular Formula	C24H27NO4
Molecular Weight	393.48 g/mol
Synonyms	Fmoc-Cycloheptylglycine-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(cycloheptyl)glycine; Fmoc-Chg-OH; Fmoc-cycloheptyl-Gly-OH; Nα-Fmoc-cycloheptylglycine; (2R/S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-cycloheptylacetic acid; Fmoc-D/L-cycloheptylglycine; Fmoc-cycloheptyl-Gly
EINECS	Contact for details

Quality Control

Our Fmoc-Gly(Cycloheptyl)-Oh is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profiles. Our quality system adheres to cGMP principles where applicable, supporting its use in pre-clinical and early-phase pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.