Description

(1R)-7-Chloro-6-Fluoro-1-[4-Methyl-2-(1-Methylethyl)-3-Pyridinyl]Pyrido[2,3-D]Pyrimidine-2,4(1H,3H)-Dione is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the research and development of new drug molecules.
• API Synthesis: Used in the multi-step synthesis of potential active pharmaceutical ingredients, especially in oncology and antiviral research.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot and commercial production scales.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control.

Basic Information

Product Name	(1R)-7-Chloro-6-Fluoro-1-[4-Methyl-2-(1-Methylethyl)-3-Pyridinyl]Pyrido[2,3-D]Pyrimidine-2,4(1H,3H)-Dione
CAS No.	2300966-23-6
Molecular Formula	C17H16ClFN4O2
Molecular Weight	362.79 g/mol
Synonyms	(1R)-7-Chloro-6-fluoro-1-(4-methyl-2-(propan-2-yl)pyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione; 7-Chloro-6-fluoro-1-[(1R)-4-methyl-2-(1-methylethyl)-3-pyridinyl]-1,3-dihydro-2,4-pyrido[2,3-d]pyrimidinedione; (R)-7-Chloro-6-fluoro-1-(4-methyl-2-(propan-2-yl)pyridin-3-yl)-1,3-dihydropyrido[2,3-d]pyrimidine-2,4-dione; CAS 2300966-23-6; Chiral Pyridopyrimidinedione Derivative; Fluorinated Pyrido[2,3-d]pyrimidine Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.