Description

Methanesulfonamide, n-[3-[[[2-[(4-Hydroxyphenyl)Amino]-5-(Trifluoromethyl)-4-Pyrimidinyl]Amino]Methyl]Phenyl]-n-Methyl- is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development of small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) for investigational drugs.
• Kinase Inhibitor Development: Its structural motifs make it valuable for research into novel kinase inhibitors targeting various disease pathways.
• Oncology Research: Used in the discovery and development of potential anti-cancer therapeutics due to the presence of the trifluoromethylpyrimidine moiety.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying biological mechanisms and target validation.
• Custom Synthesis: Supplied to fine chemical manufacturers for bespoke, multi-step synthetic routes requiring high-purity intermediates.

Basic Information

Product Name	Methanesulfonamide, n-[3-[[[2-[(4-Hydroxyphenyl)Amino]-5-(Trifluoromethyl)-4-Pyrimidinyl]Amino]Methyl]Phenyl]-n-Methyl-
CAS No.	2296719-34-9
Molecular Formula	C20H19F3N5O2S
Molecular Weight	450.46 g/mol
Synonyms	N-Methyl-N-[3-[[[2-[(4-hydroxyphenyl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide; 2296719-34-9; Methanesulfonamide, N-[3-[[[2-[(4-hydroxyphenyl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-; N-Methyl-N-(3-((((2-((4-hydroxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide
EINECS	Contact for details

Quality Control

Our Methanesulfonamide, n-[3-[[[2-[(4-Hydroxyphenyl)Amino]-5-(Trifluoromethyl)-4-Pyrimidinyl]Amino]Methyl]Phenyl]-n-Methyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere to minimize oxidation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.