Description

L-Tyrosine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-O,2-Dimethyl- is a protected derivative of the essential amino acid L-Tyrosine, featuring a fluorenylmethyloxycarbonyl (Fmoc) protecting group on the amine and methyl groups on the phenolic oxygen and α-carbon. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptide chains. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of therapeutic peptides, peptidomimetics, and biochemical research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid derivative for the automated or manual synthesis of custom peptides.
• Pharmaceutical Research: A key intermediate in the development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used to introduce modified tyrosine residues into proteins or other biomolecules for labeling or functional studies.
• Combinatorial Chemistry: Serves as a building block in libraries for drug discovery and screening.
• Biochemical Research: Employed in studies of enzyme mechanisms, protein-protein interactions, and signal transduction pathways involving tyrosine.
• Production of Specialty Peptides: For manufacturing diagnostic peptides, peptide hormones, and antimicrobial peptides.

Basic Information

Product Name	L-Tyrosine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-O,2-Dimethyl-
CAS No.	2276402-03-8
Molecular Formula	C27H25NO5
Molecular Weight	443.49 g/mol
Synonyms	Fmoc-O,2-dimethyl-L-tyrosine; Fmoc-Tyr(Me)2-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O,2-dimethyl-L-tyrosine; Fmoc-2-methyl-O-methyl-L-tyrosine; (2S)-3-(4-Methoxyphenyl)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-methylpropanoic Acid; Fmoc-2-Me-O-Me-L-Tyr-OH; Fmoc-L-Tyr(Me,Me)-OH; Fmoc-α-methyl-O-methyl-L-tyrosine
EINECS	Contact for details

Quality Control

Our Fmoc-protected amino acids are manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity, suitable for demanding synthetic applications. Each lot is subjected to rigorous analytical testing, including HPLC, NMR, and optical rotation analysis, to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.