Description

Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid, 5-Chloro-7-[[(1,1-Dimethylethoxy)Carbonyl]Methylamino]- is a high-purity, advanced pharmaceutical intermediate characterized by its specific pyrazolopyrimidine scaffold. This compound is of critical importance for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule drugs, where precise chemical structure is paramount for biological activity.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for oncology and anti-inflammatory drug candidates.
• Kinase Inhibitor Research: Serves as a core structural motif in the design and discovery of novel kinase inhibitors due to the pyrazolopyrimidine pharmacophore.
• Medicinal Chemistry & R&D: Used in lead optimization and structure-activity relationship (SAR) studies to develop compounds with improved efficacy and selectivity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.
• Biochemical Tool Compound: Can be utilized in biochemical assays to study specific enzyme interactions and pathways in academic and industrial research settings.

Basic Information

Product Name	Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid, 5-Chloro-7-[[(1,1-Dimethylethoxy)Carbonyl]Methylamino]-
CAS No.	2271470-66-5
Molecular Formula	C14H17ClN4O4
Molecular Weight	340.76 g/mol
Synonyms	5-Chloro-7-((tert-butoxycarbonyl)(methyl)amino)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; 5-Chloro-7-[[(1,1-dimethylethoxy)carbonyl]methylamino]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; tert-Butyl (5-chloro-3-(carboxy)pyrazolo[1,5-a]pyrimidin-7-yl)(methyl)carbamate; 2271470-66-5; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 5-chloro-7-[[(1,1-dimethylethoxy)carbonyl]methylamino]-; Boc-protected pyrazolopyrimidine carboxylic acid.
EINECS	Contact for details

Quality Control

Our Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with research and development grade standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.