Description

L-Norleucine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-N,5-Dimethyl- is a specialized, high-purity Fmoc-protected amino acid derivative. This compound is critical for solid-phase peptide synthesis (SPPS), enabling the controlled and efficient assembly of complex peptide sequences. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of custom peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Bioconjugation & Protein Engineering: Facilitates the site-specific introduction of modified norleucine residues into proteins and biomolecules.
• Combinatorial Chemistry Libraries: Serves as a component for generating diverse peptide libraries for high-throughput screening.
• Biochemical Research: Employed in studies of protein structure, function, and metabolism where a non-natural, stable amino acid analog is required.
• Antibody-Drug Conjugate (ADC) Development: Can be utilized in the synthesis of peptide linkers for targeted drug delivery systems.

Basic Information

Product Name	L-Norleucine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-N,5-Dimethyl-
CAS No.	2260800-15-3
Molecular Formula	C23H27NO4
Molecular Weight	381.47 g/mol
Synonyms	Fmoc-N-Me-Nle-OH; Fmoc-N-methyl-L-norleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-norleucine; Nα-Fmoc-Nα-methyl-L-norleucine; Fmoc-N-Me-Nle; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]-5-methylhexanoic acid; N-Fmoc-N-methylnorleucine; Nα-(9-Fluorenylmethyloxycarbonyl)-Nα-methyl-L-norleucine
EINECS	Contact for details

Quality Control

Our L-Norleucine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-N,5-Dimethyl- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.