Description

Mazdutide CAS NO 2259884-03-0 is a novel, long-acting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor dual agonist. This compound is of significant interest for its potential in metabolic disease research and therapeutic development. It is primarily targeted towards pharmaceutical R&D organizations and contract research organizations (CROs) engaged in the discovery of next-generation treatments for obesity, type 2 diabetes, and related metabolic disorders.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies for metabolic diseases.
• Obesity Treatment Research: Investigated for its potent anorectic effects and ability to promote weight loss through dual receptor agonism.
• Type 2 Diabetes Mellitus (T2DM) Therapy: Studied for its glucose-lowering and insulin-sensitizing properties to improve glycemic control.
• Metabolic Syndrome Studies: Used in research targeting a cluster of conditions including hypertension, hyperglycemia, and abnormal cholesterol levels.
• Non-alcoholic Steatohepatitis (NASH) Research: Explored for potential benefits in reducing liver fat and inflammation.
• Cardiometabolic Risk Reduction: Evaluated for its effects on improving cardiovascular outcomes associated with obesity and diabetes.
• Formulation Development: Utilized in the development of stable injectable formulations, including lyophilized powders and solutions.
• Bioanalytical Method Development: Employed as a standard for developing and validating LC-MS/MS and ELISA assays for pharmacokinetic studies.

Basic Information

Product Name	Mazdutide
CAS No.	2259884-03-0
Molecular Formula	C215H347N61O65
Molecular Weight	4812.3 g/mol
Synonyms	IBI362; GLP-1/GIP Dual Agonist IBI362; GIP/GLP-1 Dual Receptor Agonist; LY3305677; Mazdutide (IBI362); 7-36/8-37 hybrid peptide; OXM3; Oxyntomodulin analog; GLP-1R/GIPR co-agonist
EINECS	Contact for details

Quality Control

Our Mazdutide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, mass spectrometry for molecular weight verification, and tests for related substances, residual solvents, and endotoxins. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with relevant guidelines for pharmaceutical intermediates. Specifications can be tailored to meet specific research-grade or GMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 8.0%
Acetic Acid Content (HPLC)	≤ 15.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.