Description

(S)-9-Fluoro-3-Methyl-7-Oxo-10-(Piperazin-1-Yl)-2,3-Dihydro-7H-[1,4]Oxazino[2,3,4-Ij]Quinoline-6-Carboxylic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate belonging to the fluoroquinolone antibiotic class. This compound is critical for the research and development of novel antibacterial agents, offering a sophisticated chiral scaffold for targeted drug synthesis. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions focused on antimicrobial discovery.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key building block in the synthesis of next-generation fluoroquinolone antibiotics.
• Pharmaceutical R&D: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Serves as a critical intermediate in scale-up and process development for new drug candidates.
• Reference Standard: Employed as an analytical standard for quality control and method development in API manufacturing.
• Biochemical Research: Tool compound for studying bacterial DNA gyrase and topoisomerase IV inhibition mechanisms.

Basic Information

Item	Details
Product Name	(S)-9-Fluoro-3-Methyl-7-Oxo-10-(Piperazin-1-Yl)-2,3-Dihydro-7H-[1,4]Oxazino[2,3,4-Ij]Quinoline-6-Carboxylic Acid Hydrochloride
CAS No.	2254176-11-7
Molecular Formula	C20H21FN4O5 • HCl
Molecular Weight	452.86 g/mol (Free base: 416.41 g/mol)
Synonyms	(S)-Delafloxacin Intermediate; (S)-9-Fluoro-3-methyl-10-(1-piperazinyl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride; Delafloxacin Impurity; (S)-ABT-492 Intermediate; RX-3341 Intermediate; WO-3034 Intermediate; (S)-Chiral Fluoroquinolone Intermediate
EINECS	Contact for details

Quality Control

Our (S)-9-Fluoro-3-Methyl-7-Oxo-10-(Piperazin-1-Yl)-2,3-Dihydro-7H-[1,4]Oxazino[2,3,4-Ij]Quinoline-6-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral HPLC for enantiomeric excess, and spectroscopic identification. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.