Description

4-[(S)-4-Boc-2-Methyl-1-Piperazinyl]-6-Fluoro-7-(2-Fluoro-6-Hydroxyphenyl)-1-(2-Isopropyl-4-Methyl-3-Pyridyl)Pyrido[2,3-D]Pyrimidin-2(1H)-One is a sophisticated, high-purity pharmaceutical intermediate designed for advanced drug discovery and development. This compound is critical for medicinal chemists targeting specific kinase pathways, offering a precise molecular scaffold for creating novel therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of next-generation oncology and anti-inflammatory agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of targeted kinase inhibitors for oncology research.
• Preclinical Drug Development: Used in the discovery and optimization of lead compounds for various therapeutic areas.
• Chemical Biology Research: Serves as a probe or tool compound for studying specific enzyme functions and signaling pathways.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for the preparation of more complex, proprietary analogs and derivatives.

Basic Information

Product Name	4-[(S)-4-Boc-2-Methyl-1-Piperazinyl]-6-Fluoro-7-(2-Fluoro-6-Hydroxyphenyl)-1-(2-Isopropyl-4-Methyl-3-Pyridyl)Pyrido[2,3-D]Pyrimidin-2(1H)-One
CAS No.	2252403-85-1
Molecular Formula	C34H36F2N6O4
Molecular Weight	606.69 g/mol
Synonyms	4-[(S)-4-(tert-Butoxycarbonyl)-2-methylpiperazin-1-yl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one; (S)-4-(4-(tert-Butoxycarbonyl)-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one; CAS 2252403-85-1; Kinase Inhibitor Intermediate; Boc-Protected Piperazine Pyridopyrimidinone Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development. Identity, purity, and impurity profiles are verified using advanced analytical techniques including HPLC, LC-MS, and NMR. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.