Description

tert-Butyl (S)-4-(7-Chloro-6-Fluoro-1-(2-Isopropyl-4-Methylpyridin-3-Yl)-2-Oxo-1,2-Dihydropyrido[2,3-D]Pyrimidin-4-Yl)-3-Methylpiperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, particularly for targeting specific biological pathways. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel small-molecule drug candidates.
• Kinase Inhibitor Research: Serves as a core structural component in the development of targeted kinase inhibitors for oncology applications.
• Preclinical & Clinical Development: Used in the production of materials for pharmacological, toxicological, and early-phase clinical studies.
• Process Chemistry & Scale-Up: Essential for route scouting, optimization, and the manufacture of kilogram-scale batches under GMP conditions.
• Chemical Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control testing.

Basic Information

Product Name	tert-Butyl (S)-4-(7-Chloro-6-Fluoro-1-(2-Isopropyl-4-Methylpyridin-3-Yl)-2-Oxo-1,2-Dihydropyrido[2,3-D]Pyrimidin-4-Yl)-3-Methylpiperazine-1-Carboxylate
CAS No.	2252403-84-0
Molecular Formula	C30H35ClF N5O3
Molecular Weight	568.09 g/mol
Synonyms	(S)-tert-Butyl 4-(7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate; 2252403-84-0; BOC-protected pyridopyrimidinone piperazine derivative; (S)-enantiomer of tert-butyl 4-(7-chloro-6-fluoro-1-(2-isopropyl-4-methyl-3-pyridinyl)-2-oxo-1H-pyrido[2,3-d]pyrimidin-4-yl)-3-methyl-1-piperazinecarboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl (S)-4-(7-Chloro-6-Fluoro-1-(2-Isopropyl-4-Methylpyridin-3-Yl)-2-Oxo-1,2-Dihydropyrido[2,3-D]Pyrimidin-4-Yl)-3-Methylpiperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.