Description

7-Chloro-6-Fluoro-1-(2-Isopropyl-4-Methylpyridin-3-Yl)Pyrido[2,3-D]Pyrimidine-2,4(1H,3H)-Dione is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development programs targeting novel therapeutic agents, particularly in oncology and antiviral domains. It is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in cutting-edge drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drugs, particularly kinase inhibitors.
• Oncology Research: Used in the development of targeted cancer therapies due to its pyrido[2,3-d]pyrimidine core structure.
• Antiviral Drug Development: Serves as a precursor in the research of antiviral compounds.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing of APIs.
• Chemical Biology: Utilized as a probe or tool compound for studying specific biological pathways and target validation.
• Custom Synthesis: A starting material for the preparation of more complex, tailored molecules for client-specific projects.

Basic Information

Product Name	7-Chloro-6-Fluoro-1-(2-Isopropyl-4-Methylpyridin-3-Yl)Pyrido[2,3-D]Pyrimidine-2,4(1H,3H)-Dione
CAS No.	2252403-82-8
Molecular Formula	C₁₉H₁₆ClFN₄O₂
Molecular Weight	386.81 g/mol
Synonyms	7-Chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)-1,3-dihydropyrido[2,3-d]pyrimidine-2,4-dione; 1,3-Dihydro-7-chloro-6-fluoro-1-(2-isopropyl-4-methyl-3-pyridinyl)pyrido[2,3-d]pyrimidine-2,4-dione; 2252403-82-8; 7-Chloro-6-fluoro-1-(2-isopropyl-4-methyl-3-pyridinyl)-1H-pyrido[2,3-d]pyrimidine-2,4(3H)-dione; Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, 7-chloro-6-fluoro-1-(2-isopropyl-4-methyl-3-pyridinyl)-; 1-(2-Isopropyl-4-methylpyridin-3-yl)-7-chloro-6-fluoropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 7-Chloro-6-Fluoro-1-(2-Isopropyl-4-Methylpyridin-3-Yl)Pyrido[2,3-D]Pyrimidine-2,4(1H,3H)-Dione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.