Description

D-Phenylalanine, 4-[[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Methyl]-n-[(2-Propen-1-Yloxy)Carbonyl]- is a sophisticated, non-natural amino acid derivative designed for advanced chemical synthesis. This compound is a critical building block in the development of complex peptides and bioactive molecules, offering precise stereochemical control and orthogonal protecting group strategy. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, peptide drug discovery, and the synthesis of specialized biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid building block for the controlled assembly of custom peptide sequences.
• Medicinal Chemistry & Drug Discovery: For the research and development of novel peptide-based therapeutics, enzyme inhibitors, and receptor ligands.
• Bioconjugation and Linker Chemistry: The Alloc (Allyloxycarbonyl) protecting group enables selective deprotection under mild conditions, facilitating site-specific conjugation and labeling strategies.
• Chemical Biology Research: Used to incorporate modified phenylalanine residues into proteins or peptides to study structure-activity relationships (SAR) and protein function.
• Process Development for APIs: Serves as a high-purity intermediate in the scalable synthesis of Active Pharmaceutical Ingredients (APIs) with complex amino acid architectures.

Basic Information

Product Name	D-Phenylalanine, 4-[[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Methyl]-n-[(2-Propen-1-Yloxy)Carbonyl]-
CAS No.	2250029-23-1
Molecular Formula	C29H28N2O5
Molecular Weight	484.54 g/mol
Synonyms	Fmoc-4-(Aminomethyl)-D-phenylalanine(Alloc); Fmoc-D-Phe(4-CH2NHAlloc)-OH; 4-[(N-Alloc)aminomethyl]-D-phenylalanine, N-Fmoc derivative; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[[(2-propen-1-yloxy)carbonyl]amino]methyl]-D-phenylalanine; D-4-[[(Allyloxycarbonyl)amino]methyl]phenylalanine N-Fmoc derivative; Fmoc-D-4-(Aminomethyl)Phe(Alloc); Nα-Fmoc-Nε-Alloc-D-Lysine analog (phenylalanine-based); (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(((allyloxy)carbonyl)amino)methyl)phenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our production of this advanced amino acid derivative adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Certificates of Analysis (COA) are provided with each shipment, detailing comprehensive analytical results from techniques including HPLC, NMR, and mass spectrometry. We support compliance with cGMP guidelines for pharmaceutical intermediates and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (on anhydrous basis)
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.